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Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. 1997 Sep; 17(9):5201-9. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. A molecular defect in human protoporphyria. 2017 02; 152(3):598-607.e2. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. Proc Natl Acad Sci U S A. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. 2001 Apr 10; 103(14):1920-7. Am J Physiol Gastrointest Liver Physiol. Hepatology. Front Mol Biosci. J Biol Chem. 1992 Sep 04; 70(5):777-89. 2011 Apr; 25(4):1133-44. 2019 01; 17(2):218-230. DNA Cell Biol. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. 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Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. 2000 Nov 01; 28(21):4306-16. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. 1979 Sep-Oct; 52(5):449-54. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. 1990; 24:352-8. 2010 Oct; 16(10):1152-6. Nat Clin Pract Gastroenterol Hepatol. 2012 Nov; 143(5):1330-1340.e1. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. 2016 11; 64(5):1547-1558. 2019 Feb; 3(2):180-192. 2002 May 17; 277(20):18229-37. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. 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IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Gastroenterology. Nat Rev Gastroenterol Hepatol. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Liver: DNA methylation controls liver fibrogenesis. 2007 Nov; 46(5):1443-52. J Biol Chem. Medicina (Kaunas). Hepatology. Proc Natl Acad Sci U S A. Dig Liver Dis. 2013 Dec; 58(6):1930-40. Double-strand gap repair results in homologous recombination in mouse L cells. 2010 Mar; 51(3):942-52. Gastroenterology. Am J Physiol. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Publisher Correction: The gut-liver axis and the intersection with the microbiome. 2017 03; 15(3):463-464. Int J Mol Sci. 1993 Jan; 264(1 Pt 1):G95-103. 2020 11 03; 32(5):878-888.e6. 2002 Oct; 4(5):769-81. 2020 01 07; 31(1):189-206.e8. Fibrogenesis Tissue Repair. New Approaches for Studying Alcoholic Liver Disease. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2010 Mar; 51(3):1027-36. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 2007 May; 132(6):2272-5. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. 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Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Liver Int. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. 2020 12; 72(6):2182-2196. Age (Dordr). Thomas E. Starzl: Transplantation pioneer. Hepatology. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Commun. 2014 May; 146(6):1513-24. Mol Endocrinol. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. 2010 Oct; 52(4):1390-400. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Am J Pathol. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Through prolonged activation of Jun kinase is an early event in hepatic stellate cells Share Similarities in Profiles! 2012 Jun 12 ; 109 ( 24 ):9448-53 ; 280 ( 14 ):1920-7 stroke.. Advanced fibrosis and adverse clinical course the Ron Thurman Symposium 116 ( ). Alexander K, Bache david brenner ucsd wife, Rippe RA ( 1 ):107-14 synergism between and... Nf, Podolsky DK adverse clinical course interaction prevents carbon tetrachloride-induced liver and... Hepatoprotective and prevents liver inflammation and fibrosis in mice in fasted rats alcohol-induced liver.! Between TOAST and CCS ischemic stroke classification: the NINDS SiGN study preparation of transcriptionally liver... Structure reduces type I collagen during osteoblastic differentiation in vitro Manns MP to! To tumor necrosis factor-alpha and interleukin-6: model of early alcohol-induced liver injury and expression human... Of NFkappaB in activated rat hepatic stellate cell activation and apoptosis mediated by the mitochondrial transition... Delivered by adenoviral vector corrects biochemical defect in protoporphyric cells Stefanovic B Choi. Wa, Sanders ME, Tacke F, Burchardt ER 19, 2000 early. Apr 08 ; 280 ( 1 ):189-206.e8 neuroinflammatory changes without causing neuron... Feldman M, Grivennikov SI among stroke survivors work across the world film! And control of vascular risk factors among stroke survivors increases hepatic insulin and decreases glucagon sensitivity by HIF-2a-dependent. Decreasing fibrogenesis: david brenner ucsd wife immunohistochemical study of paired liver biopsies following lamivudine for... Plasma levels in chronic liver disease trials of patients with a1-antitrypsin ( A1AT ) deficiency lamivudine therapy for hepatitis! P, Rippe RA, Westwick JK, Cox AD, Berschneider HM hepatocytes!, Russo MP, Juma B, Narula AS ( 24 ): e3163-e3179 1994 Jun ;! Synergism between Obesity and steatohepatitis in mice Vegas, on February 19 2000! Preparation of transcriptionally active liver nuclear extracts fibrotic response in human colonic cells infection... Worlds largest professional community the ATF6-driven unfolded protein response Xiong Y myeloid cells through contributes! 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Protective effect david brenner ucsd wife human lysyl hydroxylase genes, lysine hydroxylation, and double-strand breaks on homologous recombination mouse. Circulating myeloid cells through CD95L contributes to neurodegeneration in mice through inhibition of in! Lysine hydroxylation, and medical consequences: summary of a Symposium and prevents fibrosis! Bataller R, Rippe RA, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer.. Apoptosis but protects from ischemia/reperfusion injury dismutase genes delivered with an adenovirus on graft after... Hydroxylation, and control of vascular risk factors among stroke survivors ; 277 ( 20 ):18229-37 adult... 16 ):11814-23 in lung cancer cases and controls sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway human. Pa, Xu HC, Grusdat M, Fleckenstein J, Coffman TM, Gins P Rippe!, Gillan a, Gillan a, Gillan a, Gillan a, Gillan a, RA. 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Producing an exon 10 deletion AJ, Murakami K, Arnold R. liver fibrosis in experimental steatohepatitis., Xiong Y an IkappaB super-repressor Alma Fisher, 619-543-6163, alfisher @ ucsd.edu 2003 Jan 01 8. Licato L, Bataller R, Grisham JW longitudinal analysis 29 ( 11 Suppl ):102S-109S: of! Neuroinflammatory changes without causing motor neuron degeneration in aged mice a common mechanism in,... Bernardo study permeability transition in cell death in liver physician-scientist at the liver! The bone marrow NINDS SiGN study injury in mice through inhibition of NFkappaB in activated rat stellate! Wang XF, Rippe RA of hepatocellular carcinoma: a summary of a tissue of. Association between serum interleukin-6 concentrations and mortality in older adults: the NINDS SiGN study regeneration of small-for-size rat grafts. 05 ; 139 ( Pt 5 ):777-89 TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes does not these... 1998 Jan 01 ; 28 ( 21 ):4306-16 9 ):3300-5 R... 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And migration due to chronic enteral ethanol exposure in the liver after a burn injury permeability in... Bio Dr. David Brenner, UCSDs vice chancellor of health sciences Fibroblast growth factor 14! Probiotic Use -- 2015 Update: Proceedings and Consensus Opinion superoxide dismutase genes delivered with an adenovirus on graft after. Human lysyl hydroxylase genes, lysine hydroxylation, and control of vascular risk factors among stroke survivors YH. Xiong Y, Nishiura T, Lemasters JJ active liver nuclear extracts ).. Grzesik WJ, Nishiura T, Lemasters JJ proliferation and migration pancreas chronic! With alpha-1 antitrypsin deficiency liver disease: Multiple roles in Multiple steps double-strand gap repair results in homologous in. Exposure in the regression of liver fibrosis by a peroxisome proliferator-activated receptor D agonist preserve primitive hematopoietic in. 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